Constitutional Dynamic Inhibition/Activation of Carbonic Anhydrases

The cover shows an artistic concept describing evolutional approach to the generation of dynamic inhibitors and activators Carbonic Anhydrase on both molecular supramolecular levels through implementation reversible covalent reactions non-covalent intermolecular interactions within inner active catalytic center outer enzyme microenvironment, respectively. They open up wide perspectives construct a fundamental transition from molecular/supramolecular medicinal chemistry design toward constitutional self-selection CDC strategies, for discovery powerful drug molecules polymers efficient encapsulation CO2 capture applications, More information can be found in Minireview by M. Barboiu co-workers.